Stephen Leonard received a Bachelor's degree in Chemistry from Indiana Wesleyan University and a Doctorate in Chemical Biology from the University of Michigan developing chemical tools to investigate cysteine oxidation under the guidance of Dr. Kate Carroll. His post-doctoral work with Dr. Dustin Maly at the University of Washington involved chemical genetic techniques to study Src-family kinase conformations.
Dr. Leonard rejoined Indiana Wesleyan University in 2014. His current research focus is developing selective and potent inhibitors of the oncogenic tyrosine phosphatase SHP-2 both through a traditional medicinal chemistry approach and a chemical-genetic technique using targeted monobodies.
Dr. Leonard currently teaches General Chemistry, Organic Chemistry, and other upper divisional chemistry courses. His chemistry education work focuses on the development of science identity in undergraduate STEM majors.
PHD
Chemical Biology
University of Michigan, Ann Arbor , 2014
BA
Chemistry
Indiana Wesleyan University , 2006
Learn more about Stephen's education, professional experience, and more!
Peer-reviewed journal articles:
- Reddie, K. G., Seo, Y. H., Muse, W. B., Leonard, S. E., & Carroll, K. S. (2009). Detecting sulfenic acid-modified proteins in living cells. Molecular BioSystems, 4(6), 521–531.
- Leonard, S. E., Reddie, K. G., & Carroll, K. S. (2009). Mining the thiol proteome for sulfenic acid modifications. ACS Chemical Biology, 4(9), 783–799.
- Depuydt, M., Leonard, S. E., Vertommen, D., et al. (2009). A periplasmic reducing system protects single cysteine residues from oxidation. Science, 326(5956).
- Leonard, S. E., Garcia, F. J., Goodsell, D. S., & Carroll, K. S. (2011). Redox-based probes for protein tyrosine phosphatases. Angewandte Chemie International Edition, 50(19), 4423–4427.
- Paulsen, C. E., Truong, T. H., Garcia, F. J., et al. (2012). Peroxide-dependent sulfenylation of EGFR. Nature Chemical Biology, 8(1), 57–64.
- Barrett, T. J., Pattison, D. I., Leonard, S. E., et al. (2012). Inactivation of thiol-dependent enzymes by hypothiocyanous acid. Free Radical Biology and Medicine, 52(6), 1075–1085.
- Krishnamurty, R., Brigham, J. L., Leonard, S. E., et al. (2013). Active site profiling reveals coupling between domains in SRC-family kinases. Nature Chemical Biology, 9(1), 43–50.
- Hari, S. B., Perera, B. G. K., Leonard, S. E., & Maly, D. J. (2013). Investigating inactive conformations of protein kinases. FASEB Journal, 27, 042.1.
- Vidadala, R. S. R., Ojo, K. K., Johnson, S. M., et al. (2014). Inhibitors of Plasmodium falciparum CDPK4. European Journal of Medicinal Chemistry, 74(3), 562–573.
- Leonard, S. E., Register, A. C., Krishnamurty, R., et al. (2014). Modulation of Src-family kinase interactions. ACS Chemical Biology, 9(8), 1894–1905.
- Register, A. C., Leonard, S. E., & Maly, D. J. (2014). SH2-catalytic domain linker heterogeneity. Biochemistry, 53(44), 6910–6923.
- Crowther, G. J., Hillesland, H. K., Keyloun, K. R., et al. (2016). Kinase screening against 14,000 compounds. PLoS ONE, 11(3), e0149996.
