Jolie Leonard, an IWU alumnus, obtained a Ph.D. in Molecular and Cellular Biology at the University of Michigan in Ann Arbor. While there, she studied the mechanisms by which HIV proteins alter the normal function of infected cells in order to evade detection by the immune system.
Jolie completed a 3-year postdoctoral fellowship at the University of Washington in Seattle, designing and testing candidate influenza and HIV vaccines.
Jolie joined the Department of Biology at Indiana Wesleyan University in 2014 and is continuing to research the manner in which HIV alters cellular enzyme functions to influence virus infectivity.
PHD
Molecular and Cellular Biology
University of Michigan, Ann Arbor , 2011
BS
Biology
Indiana Wesleyan University , 2005
Peer-reviewed journal articles:
- Leonard, J. A., Filzen, T., Carter, C. C., Schaefer, M., & Collins, K. L. (2011). HIV-1 Nef disrupts intracellular trafficking of major histocompatibility complex class I, CD4, CD8, and CD28 by distinct pathways that share common elements. Journal of Virology, 85(14), 6867–6881. https://doi.org/10.1128/JVI.00229-11
- Wonderlich, E. R., Leonard, J. A., Kulpa, D. A., Leopold, K. E., Norman, J. M., & Collins, K. L. (2011). ADP ribosylation factor 1 activity is required to recruit AP-1 to the major histocompatibility complex class I (MHC-I) cytoplasmic tail and disrupt MHC-I trafficking in HIV-1-infected primary T cells. Journal of Virology, 85(23), 12216–12226. https://doi.org/10.1128/JVI.00056-11
- Schaefer, M. R., Wonderlich, E. R., Roeth, J. F., Leonard, J. A., & Collins, K. L. (2008). HIV-1 Nef targets MHC-I and CD4 for degradation via a final common beta-COP dependent pathway in T cells. PLOS Pathogens, 4(8), e1000131. https://doi.org/10.1371/journal.ppat.1000131
